Gentamicin-Induced Kounis Syndrome: A Case Report and Review of Literature

Kounis Syndrome (KS) is an allergic or hypersensitivity reaction that manifests with cardiovascular symptoms. Once considered rare, it is now increasingly recognized as a cause of acute coronary spasm, even in patients without pre-existing coronary artery disease. We present a case of pre-operative gentamicin-induced KS, highlighting its pathophysiology, clinical manifestations, epidemiology, diagnosis, and management. This case is particularly notable as it involves a young female patient who developed symptoms primarily after the third dose of gentamicin - a rare occurrence, as gentamicin-induced KS has not been well-documented in literature. This case challenges the conventional perception of KS, demonstrating that it can occur in younger female patients rather than the traditionally expected demographic. The patient was managed symptomatically and kept under observation. She remains in stable condition, with a strict recommendation to avoid future exposure to gentamicin.