Analyzing Antihypertensive Drugs Floating Times for Efficiency Evaluation: A Review

Objective: This review aims to evaluate the efficacy of Gastroretentive Drug Delivery Systems (GRDDS) in enhancing the gastric residence time of antihypertensive drugs to improve drug absorption and bioavailability. Methods: The study analyzed various GRDDS formulations designed to prolong gastric residence time. Key parameters such as Total Floating Time and Floating Lag Time were measured to assess the sustained release capabilities of these formulations. A comparative analysis was conducted across different antihypertensive drugs, focusing on their floating capacities in simulated gastric fluid. Results: Among the antihypertensive drugs studied, Perindopril demonstrated the highest floating time exceeding 10 hours, coupled with the shortest floating lag time of 0.09 seconds. These findings highlight Perindopril's superior ability to remain buoyant in the gastric environment, ensuring prolonged exposure and enhanced absorption within the upper gastrointestinal tract. In contrast, other formulations exhibited varying degrees of floating capacities, influencing their gastric residence times accordingly. Conclusion: GRDDS, particularly exemplified by Perindopril, effectively prolongs gastric residence time, thereby optimizing drug absorption and bioavailability. The significant correlation observed between floating capacities and gastric residence time underscores the importance of Total Floating Time and Floating Lag Time in designing sustained-release formulations for antihypertensive medications. This approach not only improves therapeutic outcomes but also potentially reduces dosing frequency, enhancing patient compliance and treatment efficacy.