A REVIEW OF THE EMERGING TREND IN BI-LAYER TABLET TECHNOLOGY Mr. Manishkumar Prajapati*, Mr. Abhijit Mohan Kanavaje, Mr. Shaikh Naumaan NaeemA REVIEW OF THE EMERGING TREND IN BI-LAYER TABLET TECHNOLOGY

The creation of controlled release formulations with a range of characteristics to guarantee efficient drug administration is ushered in by the bi-layer tablet. By physically separating APIs, bi-layer tablets can be an effective means of preventing chemical incompatibilities and producing distinct drug release patterns. A bi-layer tablet can be used to release two medications in combination in a sequential fashion or to release a single tablet continuously, with the first layer serving as the loading dosage and the second as the maintenance dose. The next piece addresses bi-layer tablet technology, difficulties in producing bi-layer tablets, different tablet presses that are employed, quality and GMP requirements for their manufacture, different bi-layer tableting methods, and current advancements in the field of bi-layer technology. Key Words:- Bi-layer tablet, Incompatibility, multi-layer tablet, sustained release formulation.