Formulation And Development of Oral Fast Dissolving Tablets Using a Model Drug

The aim of this study was to develop fast dissolving tablets of cinnarizine by direct compression method. Micro crystalline cellulose (MCC) as diluent and super disintegrants, such as Crospovidone (CP), Cinnarizine(drug), Magnesium Stearate,Talc,Mannitol and croscarmellose Sodium were used. Fast dissolving tablets disintegrates or dissolves rapidly within few seconds due to maximized pore structure in the formulation or by the action of superdisintegrants. Infrared (IR) spectroscopy was performed to identify the physicochemical interaction between drug and polymer. IR spectroscopy showed that there was no interaction of drug with polymer. Various pre-compression parameters such as angle of repose, bulk density, tapped density, compressibility index, Hausner’s ratio were carried out to study the flow properties of powder in order to achieve uniformity of tablet weight and the values were found within acceptable limits. The powder mixtures were compressed into tablet using punch tablet machine. The formulated tablets were evaluated for hardness, thickness, weight variation, friability % drug content,in vitro disintegration time in vitro drug release and all the values were found within permissible limits. The formulation F04 containing crospovidone as superdisintegrant and MCC as diluent was found to be the optimized formulation on the basis of in vitro disintegration time and in vitro drug release. Stability studies were carried out at 400C/ 75% RH for a period of 1month for the selected formulations.