COMPARATIVE ANALYSIS OF BIOLOGIC AND TARGETED SYNTHETIC DMARDS IN THE LONG-TERM MANAGEMENT OF PSORIATIC ARTHRITIS

Background: Psoriatic arthritis (PsA) is a composite, chronic erythrogenic disease which is associated with psoriasis, it affects up to 31% of patients with specifically skin disorder. The treatment topography has evolved with significant change in the development of biologic or bDMARDs and targeted synthetic DMARDs or tsDMARDs. Aim: This study aims to supply a comprehensive and prolonged comparison of bDMARDs and tsDMARDs in the relation of long-term management of PsA, which specifically focusing on their mechanisms of action, efficaciousness, safety, attachment, and long-term outcomes. Methods: A research-based modified analysis was conducted by using clinical data for trial, overall long-term studies, and evidence of real-world helps to evaluate the performance of both drug classes. Results: Both bDMARDs and tsDMARDs demonstrate its vigorous efficacy across multiple PsA estate, with distinctive profiles in terms of administration, safety and patient’s preferences. Two main inhibitors play vital role in this research. TNF inhibitors and IL-17/IL-23 inhibitors remain the backbone of biological therapy, while JAK inhibitors and PDE4 inhibitors offer oral alternatives with competitive behavior and effectiveness. Conclusion: Treatment should be personalized based on the severity of disease, phenotypic, some co existing conditions and preferences of patients. Continued research and signified medicine strategies play a key role tin optimization of long-term PsA and its outcomes. Keywords: TNF, cytokines, analysis, long term management, keystone.