Design And Chacterization of Novel Topical Drug Delivery System

The present study focuses on the design and characterization of a novel topical drug delivery system incorporating Vitex negundo extract through microsponge technology followed by gel formulation. Vitex negundo, known for its potent anti-inflammatory and antimicrobial properties, and microsponges via the quasi-emulsion solvent diffusion technique, employing ethyl cellulose as the polymer and polyvinyl alcohol as the stabilizer. The prepared microsponges were characterized for particle size, surface morphology, entrapment efficiency, and thermal stability using techniques such as, scanning electron microscopy (SEM), and The optimized microsponges were then incorporated into a carbopol-based gel to develop a stable, non-irritant topical formulation. The gel was evaluated for physicochemical parameters, in-vitro drug release, and release kinetics. Results indicated controlled release of the active constituents, enhanced stability, and improved spreadability. This microsponge-based gel system offers a promising approach for the effective topical delivery of herbal actives, providing a controlled and targeted therapeutic effect with minimal side effects.