Research On the Formulation and Rigorous Evaluation of Aceclofenac-Loaded Matrix-Based Drug Delivery System Utilizing Naturally Derived Gum from The Satpuda Region

This research focuses on the formulation and evaluation of a matrix drug delivery system for Aceclofenac using natural gum obtained from the Satpuda region. Aceclofenac, a non-steroidal anti-inflammatory drug (NSAID), is widely used to treat pain and inflammation but often causes gastrointestinal side effects when administered conventionally. To overcome this, a sustained-release drug delivery system was developed, aiming to release the drug over an extended period, thus improving patient compliance and minimizing adverse effects. The natural gum, chosen for its biodegradable and non-toxic properties, was used as the matrix-forming agent. Matrix tablets were prepared using different concentrations of the gum and other excipients via direct compression. The formulated tablets were subjected to evaluation for their physical properties, including hardness, friability, and drug content uniformity. In vitro drug release studies were conducted using dissolution tests over 12 to 24 hours, with the aim of achieving sustained drug release. The findings revealed that the natural gum effectively controlled the release of Aceclofenac, with drug release following a controlled pattern over time. The release mechanism was observed to be diffusion-controlled, supported by the swelling properties of the gum matrix. The formulation also demonstrated stability and compatibility between the drug and the gum, as confirmed by FTIR and DSC studies. In conclusion, the natural gum sourced from the Satpuda region proved to be an efficient and sustainable material for developing a matrix-based sustained-release drug delivery system for Aceclofenac. This approach offers the potential to enhance therapeutic outcomes while reducing dosing frequency and side effects, contributing to a more patient-friendly treatment for chronic pain and inflammation.