Research Article on Formulation and Evaluation of Nimbidin Herbal Cream

Vitiligo is a chronic, idiopathic disorder that affects skin pigmentation and can significantly impact the social lives of those affected. The primary symptom of vitiligo is the appearance of white patches or lesions on the skin. Notably, some cases have shown partial re-pigmentation of de-pigmented skin after four months, indicating a reversal in disease progression. The aim of this study is to formulate and evaluate an herbal cream using neem extract and curcumin extract for the treatment of vitiligo. The cream is composed of a base that includes emulsifying wax, beeswax, stearic acid, glycerin, vitamin E oil, citric acid, distilled water, neem extract, and curcumin extract. The cream was prepared using the extemporaneous method to achieve a smooth texture and ensure proper mixing of all ingredients. The neem extract was prepared using alcohol as a solvent, taking advantage of neem’s antibacterial properties. Additionally, neem leaves are known to promote melanin production in the skin. The curcumin extract was also prepared using alcohol as a solvent.