Development And Evaluation Of Bilayer Floating Tablet For Helicobacter Pyloric Induced Ulcer Treatment Using Omeprazole And Tinidazole

Development and evaluation of bilayer floating tablet containing ulcer and antibiotic drugs. This study aims to develop a bilayer tablet containing an anti-ulcer and anti-antibiotic combination, with omeprazole as the immediate release layer and tinidazole as the sustained release layer, and to conduct in vitro release studies of the formulation. The combination of these drugs, which have complementary mechanisms of action, is intended to achieve a fixed dose, improve patient compliance, optimize formulation that enhances safety, and increase the therapeutic efficacy of the drugs. Several methods have been developed, including floating drug delivery systems, swelling and expanding systems, bio-adhesive systems, modified form systems, and high-viscosity systems. Locally active medicines, with a short window for immersion in the stomach or upper small intestine, are unstable in the intestinal or colonic region and have low solubility at high pH situations and are particularly interested in floating drug delivery systems. From this discussion it is concluded the bilayer tablet containing Anti-ulcer (Omeprazole) and anti-biotic (Tinidazole) containing bilayer tablet were prepared by using super disintegrating agent for immediate release and hydrophilic mucoadhesive / swellable polymer for achieving sustained release layer are a good means of promising therapy which achieving higher patient compliance.