Formulation And Evaluation of Griseofulvin-Loaded Invasomal Gel for Efficient Topical Delivery to Treat Dermatophytosis

The present study aimed to formulate and evaluate griseofulvin-loaded invasomal gel for efficient topical delivery in the treatment of dermatophytosis. Griseofulvin was encapsulated in invasomes using different formulations, and their entrapment efficiency, vesicle size, and stability were assessed. Formulation F3, with a high entrapment efficiency of 72.25% and an average vesicle size of 95.58 nm, exhibited superior characteristics. The in vitro drug release studies showed that the formulation achieved 98.12% cumulative drug release at 6 hours, indicating rapid release, while formulation F3 exhibited sustained drug release over 12 hours. The gel formulations also demonstrated good viscosity, extrudability, spreadability, and stability. Stability studies under different storage conditions revealed that formulation F3 maintained its drug content and viscosity over a 3-month period, suggesting its potential for long-term use. The results indicate that griseofulvin-loaded invasomal gel could offer a promising strategy for enhanced topical drug delivery for dermatophytosis treatment, providing controlled drug release and improved therapeutic efficacy.