POSSIBLE RISK FACTORS AND MECHANISMS OF PANCREATIC CANCER DE-VELOPMENT DUE TO OBESITY

Abstract The article addresses the risk factors and certain mechanisms underlying the development of obesity and pancreatic cancer. It is noted that obesity contributes to the development of metabolic syndrome, cardiovascular diseases, sarcopenia, fatty liver disease, pancreatic steatosis, hepatic adenocarcinoma, and nonalcoholic pancreatic disease. A review of the literature indicates that obesity and high BMI increase the risk of pancreatic carcinogenesis, with 30% of pancreatic cancer patients found to have pancreatic steatosis. Chronic pancreatitis (CP) has been identified as the primary factor contributing to both pancreatic steatosis and cancer in obese patients. Increasing evidence, supported by studies on both animals and humans, confirms this association. Male sex has been identified as an important risk factor for the potential link between pancreatic steatosis and malignancies of the pancreas. Additionally, the gut microbiota may be associated with pancreatic steatosis and cancer.