Therapeutic potential of stem cells: a comprehensive review

Patients with untreated illnesses and disorders now have more options because to recent developments in stem cell technology. Human pluripotent stem cells (hPSCs) and multipotent mesenchymal stem cells (MSCs) are two examples of stem cell-based therapy that has recently become a major force in regenerative medicine. Self-renewing cell types known as hPSCs are capable of differentiating into the three germ layers and other cellular phenotypes found in the human body. According to the International Society for Cell and Gene Therapy (ISCT), MSCs are multipotent progenitor cells with the capacity to differentiate into mesenchymal lineages and self-renew (although limited in vitro).Stem cell treatment has emerged as a very promising and cutting-edge area of scientific study in recent years. High expectations have been raised by the advancement of treatment techniques. The discovery of various stem cells and possible treatments based on these cells are the main topics of this review study. Stem cell genesis is followed by regulated stem cell culture and derivation in the lab. Assays for teratoma formation and quality control are crucial steps in evaluating the characteristics of the stem cells under investigation. Setting up the right environmental conditions for regulated differentiation requires the use of culture media and derivation techniques. Because of their adaptability, the utilization of graphene scaffolds and the promise of extracellular vesicle-based therapies warrant study among the many different kinds of stem tissue applications.

Publication Details

Journal
Zenodo (CERN European Organization for Nuclear Research)
Published
2025-02-13
DOI
https://doi.org/10.5281/zenodo.14866081
Primary Topic
Protein Kinase Regulation and GTPase Signaling
Type
article
Field-Weighted Citation Impact
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article

Therapeutic potential of stem cells: a comprehensive review

Zenodo (CERN European Organization for Nuclear Research)
Protein Kinase Regulation and GTPase Signaling
article

Therapeutic potential of stem cells: a comprehensive review

article en

Abstract

Patients with untreated illnesses and disorders now have more options because to recent developments in stem cell technology. Human pluripotent stem cells (hPSCs) and multipotent mesenchymal stem cells (MSCs) are two examples of stem cell-based therapy that has recently become a major force in regenerative medicine. Self-renewing cell types known as hPSCs are capable of differentiating into the three germ layers and other cellular phenotypes found in the human body. According to the International Society for Cell and Gene Therapy (ISCT), MSCs are multipotent progenitor cells with the capacity to differentiate into mesenchymal lineages and self-renew (although limited in vitro).Stem cell treatment has emerged as a very promising and cutting-edge area of scientific study in recent years. High expectations have been raised by the advancement of treatment techniques. The discovery of various stem cells and possible treatments based on these cells are the main topics of this review study. Stem cell genesis is followed by regulated stem cell culture and derivation in the lab. Assays for teratoma formation and quality control are crucial steps in evaluating the characteristics of the stem cells under investigation. Setting up the right environmental conditions for regulated differentiation requires the use of culture media and derivation techniques. Because of their adaptability, the utilization of graphene scaffolds and the promise of extracellular vesicle-based therapies warrant study among the many different kinds of stem tissue applications.

Zenodo (CERN European Organization for Nuclear Research)
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Protein Kinase Regulation and GTPase Signaling
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