The Burden of Chronic Kidney Disease: Risk Factors, Therapeutic Approaches, and Prevention

AbstractChronic kidney disease (CKD) is a progressive condition affecting millions worldwide, leading to significant morbidity, mortality, and a growing healthcare burden. Without timely intervention, CKD advances to end-stage renal disease (ESRD), necessitating dialysis or kidney transplantation, both of which are often costly and inaccessible, particularly in resource-limited settings. Early detection and effective management are critical in slowing disease progression and reducing associated complications. Individuals with diabetes and hypertension are at the highest risk and require routine kidney function monitoring. Pharmacological interventions, including angiotensin-converting enzyme (ACE) inhibitors, angiotensin II receptor blockers (ARBs), and sodium-glucose cotransporter-2 (SGLT2) inhibitors, have demonstrated efficacy in delaying CKD progression and lowering cardiovascular risks. However, socioeconomic barriers, inadequate healthcare infrastructure, and high treatment costs remain significant obstacles to optimal CKD management, especially in low-income regions. In addition to medical therapy, lifestyle modifications such as smoking cessation, weight management, and strict glycemic and blood pressure control play a crucial role in preventing CKD onset and progression. Addressing these challenges requires a multidisciplinary approach that emphasizes early diagnosis, effective treatment, and equitable access to healthcare. Strengthening screening programs, improving the affordability of renoprotective therapies, and promoting preventive strategies are essential to mitigating the global burden of CKD.Keywords: Chronic kidney disease, CKD, ESRD, CKD complications, nephrotoxicity, dialysis, kidney transplant