Giant Gluteal Liposarcoma: A Case Report

Abstract Background: Liposarcoma, a malignant neoplasm originating from adipose tissue, represents one of the most common subtypes of soft tissue sarcomas in adults. Its heterogeneous nature—encompassing well-differentiated, dedifferentiated, myxoid/round cell, and pleomorphic variants poses significant challenges in diagnosis, prognostication, and treatment. Recent advances in molecular biology and imaging have begun to reshape our understanding of liposarcoma’s pathogenesis and therapeutic vulnerabilities. We are doing this case report for clinical awareness and early diagnosis due to its unique or rare presentations with its treatment challenges and outcomes with surgical and oncological insights.4 Case Report: Here we present a case of 47-year-old female with an unusual case of a rapidly growing giant lipoma-like liposarcoma of the left gluteal region. The patient had Large gluteal swelling in the past 2 years and managed by local excision. For such unusual case of this rapidly growing tumour, a longer follow-up is needed to evaluate the outcome in these cases. We report a case of giant gluteal liposarcoma that was surgically removed in toto.3