Glioblastoma Treatment and Quality of Life in Children: A Review

Abstract Glioblastoma (GBM) is an aggressive and rare brain tumor in children, with significantly different biological and clinical features compared to adult GBM. Despite advances in treatment modalities, the prognosis for pediatric GBM remains poor, and the aggressive nature of therapies often impacts the quality of life (QoL) in affected children. This review discusses current treatment strategies, including surgery, radiotherapy, and chemotherapy, alongside emerging therapies such as immunotherapy and targeted approaches. Additionally, it evaluates the impact of these treatments on the quality of life, focusing on neurocognitive, emotional, and social aspects, and the importance of supportive care.