Intrathoracic use of tranexamic acid: Reduction of transfusions and safety in thoracic surgery

Introduction: Tranexamic acid (TXA) is an antifibrinolytic agent used to control bleeding in surgery. This study investigates the efficacy and safety of intrathoracic TXA application in thoracic surgeries. Objectives: To assess the reduction in blood transfusions and the need for reoperations, as well as the safety of intrathoracic TXA use. Methods: A total of 13 patients (84% male, mean age 32 years) undergoing pleural decortication were treated with intrathoracic TXA (1.5 g in 250 cc saline). The solution remained in place for 15-20 minutes before being rinsed. Results: 92% of patients did not require transfusions, no reoperations were necessary, and no mortalities were reported. Minor side effects were noted. Conclusion: Intrathoracic TXA effectively reduces postoperative transfusion needs and is safe, with no major complications. Further studies are needed to confirm these findings