Can ceftriaxone be diluted with Ringer's lactate?

Ceftriaxone is a bactericidal antibiotic from the third generation of cephalosporins. It works by inhibiting the synthesis of the bacterial cell wall. It is the drug of choice in the treatment of a wide variety of infections caused by both gram-positive and gram-negative bacteria. Its spectrum of activity includes Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, and Neisseria gonorrhoeae, among others. Similarly, ceftriaxone is effective against certain anaerobic bacteria, making it an option for complicated infections, such as those in the respiratory and urinary tracts, as well as in bacterial meningitis. Its effectiveness against some beta-lactamase-producing bacteria also makes it useful against resistant infections. However, as a drug administered intravenously or intramuscularly, it is essential to follow the recommendations for its preparation and administration to avoid risks associated with its use.

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Publication Details

Journal
Zenodo (CERN European Organization for Nuclear Research)
Published
2025-04-04
DOI
https://doi.org/10.5281/zenodo.15150552
Primary Topic
Antibiotics Pharmacokinetics and Efficacy
Type
article
Field-Weighted Citation Impact
0.00
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article

Can ceftriaxone be diluted with Ringer's lactate?

Zenodo (CERN European Organization for Nuclear Research)
Antibiotics Pharmacokinetics and Efficacy
article

Can ceftriaxone be diluted with Ringer's lactate?

article en

Abstract

Ceftriaxone is a bactericidal antibiotic from the third generation of cephalosporins. It works by inhibiting the synthesis of the bacterial cell wall. It is the drug of choice in the treatment of a wide variety of infections caused by both gram-positive and gram-negative bacteria. Its spectrum of activity includes Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, and Neisseria gonorrhoeae, among others. Similarly, ceftriaxone is effective against certain anaerobic bacteria, making it an option for complicated infections, such as those in the respiratory and urinary tracts, as well as in bacterial meningitis. Its effectiveness against some beta-lactamase-producing bacteria also makes it useful against resistant infections. However, as a drug administered intravenously or intramuscularly, it is essential to follow the recommendations for its preparation and administration to avoid risks associated with its use.

Zenodo (CERN European Organization for Nuclear Research)
Universidad Nacional de Colombia (CO)
Good health and well-being
Openalex Percentile: Top 47%
Antibiotics Pharmacokinetics and Efficacy
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