ORIGIN, DIAGNOSIS AND MODERN CLINICAL DIAGNOSTIC METHODS OF HYPERTENSION

Many RCTs have shown that monotherapy reduces blood pressure only in a limited number of hypertension cases, and most patients require a combination of at least two drugs for satisfactory blood pressure control. A meta-analysis of more than 40 studies has shown that a rational combination of two drugs from any two classes of antihypertensive agents significantly improves the degree of blood pressure reduction than increasing the dose of a single drug. Another advantage of combination therapy is that there may be physiological and pharmacological synergy between drugs from different classes, which not only leads to a significant decrease in blood pressure and good tolerability. Combination therapy also allows you to suppress counter-regulatory mechanisms of blood pressure increase. Rational combinations of antihypertensive drugs are ACE inhibitors + TD; BRA + TD; ACE inhibitor + AC; BRA + AK; dihydropyridine AC + BB; AK + TD; BB + TD [1].