Evaluation of Coagulation Profile in Pregnancy Induced Hypertension

Background: Pregnancy induced hypertension (PIH) is one of the most common causes of both maternal and neonatal morbidity and associated with adverse pregnancy outcomes. Profound changes in coagulation and fibrinolytic system occur during normal pregnancy causing hypercoagulable state. Early identification of high risk women and monitoring derangements in their coagulation system are surely pivotal in the prevention of complications. Hence, this study was undertaken to compare the coagulation profile in pre-eclamptic and eclamptic patients with normotensive pregnant patients Hypertension is one of the common medical complications of pregnancy and contributes significantly to maternal and perinatal morbidity and mortality. Aim of this study to evaluate the coagulation profile in pregnancy induced hypertension. Methods: Present study was carried out in the Department of Obstetrics and Gynaecology, DMCH, Laheriasarai, Bihar on 100 PIH cases from July 2023 to December 2023. Coagulation profile (PT, aPTT, INR and D-dimer) was done in all cases and values were correlated with the severity of PIH. Results: Total of 100 cases were included in the study. 32 were mild GH, 17cases were severe GH, 35 cases were mild pre-eclampsia and 16 cases were in severe pre-eclampsia group. Prolonged PT, aPTT and D-Dimer was seen in 15 cases, 42 cases and 38 cases respectively. In our study we observed increased mean aPTT of 31.61±2.89 and increased D-Dimer of 0.34±0.31 in severe pre-eclampsia patients. Hence we emphasize that raised aPTT, D-Dimer are alarming signs for aggressive treatment. Conclusion: Raised aPTT and D-dimer are fairly good indicator of severe preeclampsia and needs aggressive treatment.