Therapeutic Approaches and Efficacy of von Willebrand Factor in von Willebrand Disease Treatment

This systematic review evaluates therapeutic approaches for von Willebrand Disease (VWD), focusing on the role of von Willebrand factor (VWF) in treatment. Using the Synthory.AI service, the review adheres to PRISMA guidelines, analyzing studies from 2010 to 2024. Seven articles were included, emphasizing VWF's role in stabilizing factor VIII, which enhances treatment efficacy and reduces bleeding episodes. Despite promising results, variability in patient response and methodological limitations necessitate individualized treatment strategies and further research. Future studies should adopt prospective designs with larger, diverse populations to improve therapeutic strategies and patient outcomes.