Myonectin: The Muscle's Signal to Metabolic Harmony

Myonectin is a skeletal muscle-secreting cytokine with a molecular size ranging from 55-77 kDa. It was first discovered by Seldin and his coworkers in 2011. This myokine is secreted predominantly by the skeletal muscle in response to nutrient availability and physical activity. Myonectin is known to have a significant role in somatic metabolism, lipid metabolism, modulation of skeletal mass and function, cardio protectivity, etc. Physical activity being a major stimulator of this myokine production, plays substantial role in the prevention as well as the progression of metabolic diseases and skeletal muscle degeneration. From its initial discovery in 2012, still its biological, pathophysiological, physiological, and pharmacological functions with special emphasis on the amelioration of serious ailments are yet to be delved into deeply. Myonectin is involved in micronutrient metabolism and attenuation of metabolic disorders. Many research papers do not seem to investigate the correlation of myonectin in attenuating various disease conditions. Also, many research papers have delineated the significance of myonectin and its correlation with metabolic syndromes. As a science pursuer, it is important to broadcast the science of myonectin to future biology researchers which will contribute to the knowledge of researchers, teachers, and health professionals. In this review, we have attempted to have a fundamental knowledge about myonectin which will induct the researchers to expedite the studies involving myonectin for the benefit of human health.