POSTMORTEM MOLECULAR DIAGNOSTICS: NOVEL APPROACHES IN FORENSIC PATHOLOGY

Postmortem Molecular Diagnostics: Novel Approaches in Forensic Pathology. Forensic pathology has traditionally relied on histopathological, toxicological, and gross anatomical examinations to determine the cause of death. However, recent advancements in molecular diagnostics have introduced novel approaches that enhance accuracy and objectivity in forensic investigations. Postmortem molecular diagnostics involve the analysis of DNA, RNA, proteins, and metabolites to uncover underlying pathological processes, genetic predispositions, and biochemical changes occurring after death. This paper explores emerging techniques such as DNA methylation profiling, postmortem metabolomics, and exosomal biomarker analysis in forensic pathology. The application of next-generation sequencing (NGS) for detecting genetic mutations associated with sudden cardiac death and inherited disorders is also discussed. Furthermore, the integration of artificial intelligence (AI) and machine learning in forensic molecular analysis offers promising prospects for cause-of-death determination. By incorporating molecular diagnostic tools, forensic pathology can move beyond conventional methods, improving the precision of postmortem investigations. This study highlights the potential of these novel approaches in enhancing medico-legal decision-making and advancing forensic science.