Anti- Atherosclerotic Activity of Salvia Splendens On Triton X- 100 Induced Atherosclerosis in Experimental Animal

Herbal plants contains several bioactive constituents may possess potential cardioprotective effects. The objective for present research work is to investigate herbal medication for atherosclerosis. The attempt is made to investigate this plant with promising effectiveness against atherosclerosis. Therefore the present study is used to evaluate anti-atherosclerotic activity of Salvia splendens in triton x -100 induced atherosclerotic rat model. Atherosclerosis were induced in male wistar rats by intraperitoneal administration of Triton X-100mg/kg body weight for 21 days. The methanolic extract of Salvia splendens leaves (100, 300 mg/kg) administered orally to Triton x- 100 treated rats for next 21 days. Rats were subjected to evaluate general parameter and biochemical parameters. Physical parameters were estimated at 1, 7, 14, 21 days. Biochemical parameters were also estimated in the same intervals by collecting the blood samples from tail vein under mild ether anesthesia. Then the rats were sacrificed on 22nd day, the heart was dissected out for histopathological studies. The elevated serum biochemical parameter such as TC (total cholesterol), LDL (low density lipoprotein), VLDL (very low density lipoprotein), HDL (high densisty lipoprotein, TG (triglyceride) and AI (atherogenic index). Triton X- 100 treated rats were reverted back approximately near to normal after the treatment of Salvia splendens leaves at a doses of 100 and 300 mg/kg. Salvia splendens leaves possess protective action against Triton X- 100 induced atherosclerosis in wistar rats which may be attributed by its antioxidant, anti-inflammatory and anticoagulant effect.