Protecting Hearing: The Engineering of a Cochlear Cooling Device in Cisplatin-Induced Ototoxicity

Cisplatin, a widely used chemotherapeutic agent, is known for its effectiveness in targeting rapidly dividing cancer cells but also causes significant ototoxicity, leading to irreversible hearing loss and tinnitus. This study explores the potential of an engineered cochlear cooling device (CCD) to mitigate these effects by reducing localized blood flow to the cochlea, thereby limiting cisplatin exposure to auditory hair cells. Inspired by the established efficacy of scalp cooling in preventing chemotherapy-induced alopecia, this research aims to adapt similar principles to the ear. Using computational simulations via SimScale, heat transfer data, and 3D modeling, the CCD was designed to induce vasoconstriction while ensuring patient comfort and safety. The study evaluates the feasibility of localized cooling, its impact on cochlear circulation, and the potential risks associated with prolonged exposure. By addressing a critical gap in oncology-related hearing preservation, this research proposes an innovative, non-invasive approach to reducing cisplatin-induced auditory damage, ultimately enhancing the quality of life for cancer patients and survivors.