Design And Characterization of Empagliflozin Tablets

Objective: The aim of the present study is to formulate and evaluate Empagliflozin controlled release tablets. Method: Controlled release tablets are prepared using emulsification-solvent evaporation method involves dissolving the polymer and drug in an organic solvent, forming an emulsion by dispersing this solution in an aqueous phase containing an emulsifier and then evaporating the solvent to form Granules. These Granules are collected, washed and dried to obtain the final product, which is typically used for controlled or sustained release formulations Results: Assay analysis identified formulation F9 as the optimized version, showcasing superior drug release performance with over 95% cumulative drug release at 12 hours. In vitro dissolution studies reinforced F9's efficacy, demonstrating consistent drug release profiles. Accelerated stability studies affirmed the robustness of F9, with minimal changes in weight variation, thickness, hardness, and friability over three months. Conclusion: The analysis underscores the quality, efficacy, and stability of Empagliflozin CR Tablets, with F9 selected as the optimized formulation based on excellent drug release performance and stability findings.