PHENO-GENOTYPIC CORRELATION OF M. TUBERCULOSIS RESISTANCE TO NEW DRUGS

This study investigates the correlation between phenotypic and genotypic resistance patterns of Mycobacterium tuberculosis to new anti-TB drugs, including bedaquiline, delamanid, and linezolid. A total of 240 clinical isolates from drug-resistant TB patients in Uzbekistan were analyzed. Phenotypic drug susceptibility testing (DST) was compared with whole-genome sequencing (WGS) data to assess mutation profiles in resistance-associated genes. Mutations in Rv0678, ddn, and rplC were evaluated. The overall concordance between genotypic and phenotypic results was 91.5%. The findings support the reliability of WGS-based diagnostics and highlight its importance for rapid and accurate detection of resistance to new TB drugs.