Screening Of Medicinal Bioactive Compounds in Endophytic Fungi Cladosporium Cladosporioides for Its Antibacterial And Cytotoxic Activities

The endophytic micro-fungi Cladosporium cladosporioides isolated from leave sample of Lantena camera and GC-MS analysis revealed the bioactive compounds in ethyl acetate and methanol extract of C. cladosporioides. The ethyl acetate broth extract of C. cladosporioides recorded 16 compounds many applications such as oleic acid used as emulsifying agent, anticancer effect, reduce blood pressure, reduction in the risk of coronary heart disease, antioxidant, anti-polymerization agent and used in asthma inhaler, 9-octadecenoic acid (E) used as preparation of lotion and pharmaceutical solvent, 9-octadecenoic acid (Z)-2,3-dihydroxypropyl ester uses as antifoam in juice processing, lipophilic emulsifier for water in oil application, cosmetics, encapsulating agent, sun care products, moisturizer, emulsifier and flavouring agent followed by 6-octadecenoic acid(Z) used as anti-irritant, hydrating agent, anti-aging agent, anti-oxidant and used in cosmetics. The compound tributyrin used as antineoplastic activity and used in the treatment of prostate cancer and inflammatory bowal disease. Erucic acid used as a binder for oil paints. The antibacterial activity recorded in four different pathogenic bacteria such as E. coli, Staphylococcus aureus, Pseudomonas auroginosa and Klebsiella pneumoniae. The ethyl acetate and methanol crude extract of C. cladosporioides produce zone of inhibition around the well. The anticancer activity was analysed by MTT assay, it gives the information about antiproliferative capacity of methanol extract of C. Cladosporioides. The IC50 Value of tested sample is 183.5 µg/ml and methanol extract were used as a sample to treat HeLa cell line.