Novel Heuristic Parameters in Coronary Artery Disease Prevention - Theoretical Equations and Considerations

Many factors are associated with the incidence and progression of coronary artery disease. Still, the exact mechanisms and pathophysiology are not clearly understood. The process of atherosclerosis remains an enigma, though some basic mechanisms and pathophysiology are known. There are some risk factors associated with some clinical conditions, which appear protective based on the clinical experience. Heuristically, the weightage and performance are represented by the equations. The factors include chronic obstructive lung disease, chronic liver diseases, cataract formation, and chronic renal failure, where the incidence and progression are slower. However, further mechanisms like hypoxic-ischemic growth factors – collateral formation, Estrogen - VEGF, dystrophic calcification mechanisms, and parathyroid hormone or calcium-related metabolism through 1,25 dihydroxy cholecalciferol could play an active role in etiopathogenesis respectively. Understanding and utilizing the underlying pathophysiology and mechanisms can be highly productive in the prevention, progression, and treatment of coronary artery disease.