A Holistic and Multidisciplinary Approach to Undiagnosed Diseases from the Perspective of Hodge Assumption

This paper presents an original and holistic hypothesis aimed at understanding certain medically unexplained or misinterpreted conditions, particularly those affecting the skin and connective tissues. Grounded in the Hodge Conjecture, the approach is expanded within a topological and biomechanical framework. The hypothesis suggests that microstructural spiral formations, topological knots, and epidermal folding may lead to physical displacement of hair follicles, localized fibrosis, chronic inflammation, and symptoms resembling conditions such as rosacea, alopecia, and basal cell carcinoma. The hypothesis emerges from the amateur effort of the author—who holds no formal medical degree or academic title—to interpret physical patterns observed on their own body through an interdisciplinary lens. The content is thus based not on clinical expertise but on prolonged personal observation and visual analysis.Over five years of personal documentation and intervention, consistent physical patterns including dermal tension lines, follicular misalignments, and reactive fibrosis have been recorded through visual analysis and photographic evidence. Despite its amateur nature, this study challenges conventional biomedical paradigms by proposing a structural and topological foundation for many unexplained symptoms. It also encourages a broader, multidisciplinary diagnostic perspective grounded in intuition and pattern recognition. “Diseases are not approached from the perspective of classical medicine, but through the lens of disruptions in topological systems. (Note added – content will be completed and references will be included.)” After the content was edited, it was translated into English with artificial intelligence support without losing its format.