EVALUATION OF THE WOUND HEALING EFFICACY OF THE FORMULATED BIOMATERIAL DRESSING IN THE ANIMAL MODEL

Abstract Wounds are characterized as the breakup of the tissue's anatomical and cellular continuity, brought on by chemical, physical, or immunological factors. While the wound healing process involves restoration of the integrity of the damaged tissue, chronic wounds present a significant problem to both the patient and the doctor. Selection of appropriate wound dressings accelerates the healing process, especially in the case of nonhealing wounds it is crucial to find the appropriate therapeutic method to improve the patient’s well-being. In recent times, nanoparticles have gained importance for their anti-microbial and wound-healing effects. Our study involves the incorporation of the seed husk extract of psyllium doped silver nanoparticles (AgNps) in combination with the Human Amniotic Membrane (HAM) to use as a wound dressing in a full-thickness biopsy punch model in Wistar Albino Rats. The wound closure percentage was analyzed, and histopathological studies were performed. The results demonstrated the efficient wound repair and regenerative activity of formulated wound dressing in comparison to the control concluding its efficiency in In vivo studies.