Therapeutic Effect Of Jatropha Multifida Linn. Ethanol Extract And Its Fraction On High Fat Diet And Streptozotocin Induced Diabetic Nephropathy In Rats

The present investigation has been carried out on leaves of Jatropha multifida Linn. The effect of ethanol leaf extract (JMEE) and its hexane fraction (JMHF) were investigated in HFD and STZ (40 mg/kg) induced diabetic rats and its histopathological study in the kidney tissues. Under histopathological analysis, the diabetic rat’s proximal convoluted tubules showed tubular necrosis with loss of their brush boundary, glomerular enlargement, interstitial space infiltration by lymphocytes, and thickening of the basement membrane. Jatropha multifida extracts lowered blood glucose level. While out of the two, maximum reduction was seen in JMHF at 200 mg/kg. The result of the present study is also justified by histopathological examinations of the kidney. This may be due to the active phytoconstituents isolated from the fraction of the 50% ethanol extract of the leaves. Phytochemical analysis of extract and fraction indicated high concentrations of flavonoids, phenolic acid and saponins. The kidney of the diabetic rats was observed to nearly return to its normal histological architecture after treatment with JMHF and can therefore be employed as a substitute medication to treat Type 2 diabetes and associated nephro-complications.