Formulation And Evaluation Of Clarithromycin Gastroretentive Floating Tablets For Site-Specific Drug Delivery

Clarithromycin is a macrolide antibiotic it is used to treat a wide variety of bacterial infections this medication can also be used in combination with anti-ulcer medications to treat certain types of stomach ulcers. Clarithromycin often used in treating infection caused by Helicobacter pylori (H. pylori). These infections require the drug to remain in contact with the stomach lining for an extended period to be effective. GRDDS represent a cutting-edge advancement in pharmaceutical technology, designed to increase the time a drug spends in the stomach and upper GI tract. By prolonging gastric retention, these systems can enhance the absorption of drugs with a narrow absorption window, improve bio availability, reduce the frequency of dosing, and boost patient compliance. Floating tablets of clarithromycin where prepared by using a strategic blend of natural polymers, including xanthan gum, along with synthetic polymers like HPMC K4M and HPMC K100M. Sodium bicarbonate was included as a gas generating agent. The tablet was evaluated for tablet hardness, thickness, floating lag time, swelling index and T90%, were all with in the acceptable limits of USP specifications. The results demonstrated a significant impact of the polymer blend on T90%, effectively prolonging the availability of clarithromycin F6 in the stomach for up to 9.4 hours compared with other formulation and was concluded optimized one.