The Impact of Ayurvedic Interventions on Primary Hypothyroidism with Obesity: A Focus on critical analysis of Krimighnadi Kashaya as a Shamanaoushadhi and Shakotaka Taila for Pratimarsha Nasya

Primary hypothyroidism or underactive hypothyroidism is a condition wherethe thyroid gland functions affected with elevation in thyroid stimulating hormone(TSH) >10 mU/L with free t4 level below the normal range exhibiting features likeweight gain, dry skin, cold intolerance, depression etc. The prognosis of the disease hasa wider impact on other system like respiratory, cardiac, gastrointestinal, metabolic,skin, renal and musculoskeletal systems exhibiting various clinical features.In Primary hypothyroidism with Obesity as per Ayurveda Samprapti, Aharaja,Viharaja, Manasika and Jatajanya nidana’s acts as a Moola karana in Vyadhi utpatti,causing Vruddi of Kapha, Vata Dosha’s and Kshaya of Pitta, leading to Agnivaishamyata (Jatharagni) further causing Rasa and Medho dhatvagni vyatyasa. InModern science the clinical pathology is correlated to Gut brain thyroid axisdisturbances linking to the disease manifestation.In present clinical study, the Chikitsa principle is Nidana parivarjana,Shamana by Krimighnadi Kashaya along with Shakotaka Taila for Pratimarsha Nasya,fuurther implementation of proper Dinacharya and Pathya Apathya which help inmanaging the Vyadhi by increasing Agni bala, balancing the tridosha, Rasa and Medodhatu functions.