CLINICAL EFFICACY OF LAPAROSCOPY IN THE TREATMENT OF EARLY ENDOMETRIAL CANCER AND ITS IMPACT ON PATIENTS' SEXUAL FUNCTION

The study aims to rigorously assess the clinical efficacy of laparoscopic surgery ascompared to traditional laparotomy for the treatment of early-stage endometrialcancer, with a specialized focus on its subsequent impact on patients' sexualfunctionality. A retrospective analysis was executed, involving 76 patients diagnosedwith early-stage endometrial cancer and treated at our institution between February2021 and February 2022. Patients were bifurcated into two cohorts: one subjected tolaparotomy (n=38), and the other to laparoscopic surgery (n=38). The study undertooka comprehensive analysis of perioperative metrics, postoperative complications, andboth pre- and postoperative evaluations of sexual function, nutritional markers (serumtotal protein [TP], albumin [ALB], and prealbumin [PAB]), and inflammatory indices(C-reactive protein [CRP], tumor necrosis factor-α [TNF-α], and interleukin-6 [IL-6]).Laparoscopic intervention manifested a statistically significant reduction in operativeduration, intraoperative hemorrhage, time to postoperative flatus, and overallhospitalization period compared to the laparotomy group (P<0.05). The quantity oflymph nodes excised was statistically equivalent between the two modalities (P>0.05).Sexual function parameters remained relatively stable postoperatively in the laparoscopic cohort, in stark contrast to a notable decline in the laparotomy group(P<0.05). Additionally, the laparoscopic approach demonstrated superiorpostoperative nutritional and inflammatory profiles (P<0.05) and a markedly lowercomplication incidence of 13.16% vis-à-vis 34.19% in the laparotomy arm (P<0.05).Laparoscopic surgery emerges as a less invasive yet equally efficacious modality forthe treatment of early-stage endometrial cancer, delivering comparablelymphadenectomy outcomes to laparotomy. The approach not only mitigates the rateof postoperative complications but also exerts a preservative effect on sexual functionand engenders a more favorable postoperative inflammatory and nutritional milieu.