Aromatase inhibitors in breast cancer.

This article discusses the role of aromatase in estrogen synthesis and its implications for breast cancer treatment. Aromatase is an enzyme that converts androgens into estrogens, and its expression is regulated by various factors, including gonadotropins and obesity-related inflammation. The article also explores the mechanisms and efficacy of aromatase inhibitors, such as anastrozole, letrozole, and exemestane, which are used to treat estrogen receptor-positive breast cancer.