Different Experimental Models for Hepatotoxicity; A Review

Medication and substance-induced liver damage stands among the main reasons drugs get withdrawn from distribution which potentially requires liver transplantation and leads to fatal consequences. This assessment describes the biological processes used by liver-damaging drugs to harm liver tissue and demonstrates the vital role which experimental animal testing plays in studying this pathology. The research explains that drug-induced reactive metabolites cause hepatotoxicity through their specific interactions with biological substances which trigger oxidative stress while promoting both inflammation and apoptosis processes. These mechanisms require study to uncover new therapeutic targets which will help enhance clinical hepatotoxicity management.