Multicorder - Enabling the Future of POC Diagnostics and Screening

Bio: Dr Chunxiao Hu is a Lecturer in Biomedical Engineering at the University of Glasgow. His research focuses on developing miniaturised portable microsystem platforms by using advanced technologies such as microfluidics, nanofabrication, surface functionalization for biomedical applications. Current projects include Highly integrated chemical sensors (electrical and optical) for multiple detection of biomarkers for early cancer diagnostics; CMOS based ISFET for fast antimicrobial susceptibility testing; Wearable biosensor for continuous monitoring of stroke; Microfluidic device for neurodegenerative diseases; Microfluidic device for electrophysiological analysis of drug uptake in nematodes. Abstract: Precision metabolomics and quantification for cost-effective rapid diagnosis of disease are the key goals in personalized medicine and point-of-care testing. At present, patients are subjected to multiple test procedures requiring large laboratory equipment. Here, we present a versatile single complementary metal–oxide–semiconductor chip forming a platform to address personalized needs through on-chip multimodal optical and electrochemical detection that will reduce the number of tests that patients must take. The chip integrates interleaved sensing subsystems for quadruple-mode colorimetric, chemiluminescent, surface plasmon resonance, and hydrogen ion measurements. These subsystems include a photodiode array and a single photon avalanche diode array and an array of ion sensitive field-effect transistors. The sensor arrays are distributed uniformly over an active area on the chip surface in a scalable and modular design. Bio-functionalization of the physical sensors yields a highly selective simultaneous multiple-assay platform in a disposable format. We have demonstrated its versatile capabilities through various applications such as CVD, prostate cancer diagnosis and bleeding disorders monitoring. Further details on this event can be found at: Multicorder – Enabling the Future of POC Diagnostics and Screening (futurebloodtesting.org) Further details on the full webinar series can be found here: https://futurebloodtesting.org/events/future-blood-testing-webinar-series/ YouTube Link: Multicorder - Enabling the Future of POC Diagnostics and Screening - Dr Chunxiao Hu (youtube.com) This video is an output from the Future Blood Testing Network which is funded by EPSRC under Grant Number EP/W000652/1