Coenzyme Q10 supplementation inhibits elevated transaminases during MC-LR induced toxicity in mice

Microcystin (MC-LR) is the most hazardous cyanotoxin present in water bodies, originating as by-products of cyanobacterial metabolism. Present study was planned to assess the role of coenzyme Q10 on aspartate aminotransferase and alanine aminotransferase during MC-LR induced toxicity. The animals of normal control group (N) received water and normal diet ad libitum and (MC-LR as well as MC-LR+Q) group received MC-LR (10 μg/kg bw/day, ip) for 14 days. MC-LR treated mice were co-administered with coenzyme Q10 (MC-LR+Q) (10 mg/kg bw/day, im) for 14 days. The findings of the study indicated that the administration of coenzyme Q10 resulted in a decrease in the levels of aspartate aminotransferase and alanine aminotransferase in the liver, kidney and heart of MC-LR mice, indicating that it has the potential to fulfil therapeutic purposes.