Synthesis and biological evaluation of 1,2,4-oxadiazole linked imidazopyrazine derivatives as anticancer agents

A series of new 1,2,4-oxadiazole linked imidazopyrazines(10a-j) were synthesized and evaluated for their cytotoxic activity against various human cancer cell lines, such asMCF-7 (breast), A549 (lung), and A375 (melanoma).These compounds showed moderate to appreciable anticancer activities.Among them, compounds 10b, 10c, 10d, 10f and 10i were showed more potent activity than adriamycin

Publication Details

Journal
Zenodo (CERN European Organization for Nuclear Research)
Published
2024-09-22
DOI
https://doi.org/10.5281/zenodo.13825480
Primary Topic
Synthesis and biological activity
Type
article
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article

Synthesis and biological evaluation of 1,2,4-oxadiazole linked imidazopyrazine derivatives as anticancer agents

Zenodo (CERN European Organization for Nuclear Research)
Synthesis and biological activity
article

Synthesis and biological evaluation of 1,2,4-oxadiazole linked imidazopyrazine derivatives as anticancer agents

article en

Abstract

A series of new 1,2,4-oxadiazole linked imidazopyrazines(10a-j) were synthesized and evaluated for their cytotoxic activity against various human cancer cell lines, such asMCF-7 (breast), A549 (lung), and A375 (melanoma).These compounds showed moderate to appreciable anticancer activities.Among them, compounds 10b, 10c, 10d, 10f and 10i were showed more potent activity than adriamycin

Zenodo (CERN European Organization for Nuclear Research)
Good health and well-being
Openalex Percentile: Top 70%
Synthesis and biological activity
DOIOpen Access PDFOpenAlex
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Synthesis and biological evaluation of 1,2,4-oxadiazole linked imidazopyrazine derivatives as anticancer agents · Zenodo (CERN European Organization for Nuclear Research) (2024) | TGRS Research Map | TGRS