Newly synthesized compounds from 2- hydrazino benzothiazole: Characterization, and evaluation of their antibacterial potential

Abstract:Serial of 1-tetra-O-benzoyl-β-D-glucosyl-3-(2)-hydrazino-1, 3-substituted benzothiozolyl thiocarbamide has been synthesized by the interaction of two pharmocophores, tetra-O-benzoyl-β-D-glucosyl isothiocyanates and amine substituted 2-hydrazino-1,3-benzothiazoles in acetone medium. The reaction mixture was kept at room temp for 24 hrs. In acetone medium. Acetone is evaporated then product is recrystallised by petroleum ether (60-80%). Benz-fused compounds have been employed in the synthesis of various compounds which show very potential pharmacological activities.Benzothiazole is a privileged bicyclic ring system. It contains a benzene ring fused to thiazole ring. The small and simple benzothiazole nucleus is present in compound involved in research aimed at evaluating new product that possesses interesting biological activity. Benzothiazole is a heterocyclic compound weak base, having varied biological properties and still of great scientific interest now a day. They are widely found in bioorganic and medicinal chemistry with application in drug discovery.The identities of these newly synthesised compounds have been established on the basis of usual chemical transformations and IR, 1H NMR and Mass spectral studies. The antibacterial and antifungal activities of also reported. Some of these derivatives exhibit significant antimicrobial activity. These compounds show appreciable activity towards these microorganisms like Escherichia coli, Staphylococcus aureus, Salmonella typhimurium, and Klebsiyella species, and antifungal activity against Aspergillus Niger and Candida albicance.