Synthesis and Biological Actisvity of Hydroxy Chalcone Their Pyrazole and Isoxazole Derivatives.

Abstract: The Heterocyclic compounds and its derivative have wide scope in chemistry and its Shows different Biological Activities due to this intention researcher attract to work. The Chalcone Structure contain two aromatic ring linked by an aliphatic three carbon chain having alpha beta unsaturated ketone with reactive ethylenic group.in claisen-schimdt condensation equimolar quantities of aromatic aldehyde (without alpha hydrogen) and aromatic ketone (with active –CH group) React in the presence of Condensing reagent.in the present work 3-Hydroxy benzaldehyde react with 1,4-Benzodioxane 6-yl methyl ketone in the presence of potassium hydroxide to form 3-Hydroxy chalcone. Chalcone identification was done with the help of thin layer chromatography.the newly synthesized 3-hydroxy chalcone was further reacted with hydroxylamine hydrochloride and hydrazine hydrate the presence of sodium acetate in ethanol was refluxed. We obtain Isoxazole and Pyrazole derivative of 3-hydroxy chalcone and this Derivative are confirmed with the help of TLC.