A Review On Memory, Alzheimer's Disease Pathophysiology, Treatment, And Animal Models

Memory is vital to experiences and related to limbic systems, it is the retention of information over time for the purpose of influencing future action. Memory is the ability to take in information, store it, and recall it at a later time. Information can be viewed as passing through several storage "buffers" of differing capacity and duration. Alzheimer’s disease acknowledged as progressive multifarious neurodegenerative disorder, is the leading cause of dementia in late adult life. Pathologically it is characterized by intracellular neurofibrillary tangles and extracellular amyloidal protein deposits contributing to senile plaques. Over the last two decades, advances in the field of pathogenesis have inspired the researchers for the investigation of novel pharmacological therapeutics centered more toward the pathophysiological events of the disease. Currently available treatments i.e. acetylcholinesterase inhibitors (rivastigmine, galantamine, donepezil) and N-methyl D-aspartate receptor antagonist (memantine) contribute minimal impact on the disease and target late aspects of the disease. These drugs decelerate the progression of the disease, provide symptomatic relief but fail to achieve a definite cure.