An Indications, Off-Label Uses, Mechanism of Action, Pharmacokinetics, Administration, Adverse Effects, Contra Indications of Niacin B3

Niacin, also known as vitamin B3, belongs to the water-soluble B complex group and is observed in various foods namely bran, yeast, eggs, peanuts, poultry, red meat, fish, whole-grain cereals, legumes, and seeds. This essential vitamin plays a role in cellular metabolism as a vital component especially in the oxidized state of nicotinamide adenine dinucleotide (NAD, or coenzyme 1) and the reduced form of nicotinamide adenine dinucleotide phosphate (NADP, or coenzyme 2). These coenzymes are involved in an active manner particularly in essential oxidation-reduction reactions, playing key roles in glycolysis, pyruvate metabolism, protein and amino acid metabolism, pentose biosynthesis, glycerol metabolism, synthesis of high-energy phosphate bonds, and fatty acid metabolism. Niacin assists regarding management of hyperlipidemia and is used off-label in treating pellagra, as an adjuvant particularly for discoid lupus erythematosus, and for reducing dermatological and neurological symptoms linked to NAXD and NAXE deficiencies. This activity explains about the mechanism of action, indications, dosing, administration, and contraindications of niacin.