In Vitro Evaluation of Antifungal Activity of Series of 2-Phenyl-3-(6-aryl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-3-yl)-4H-4-chromenone Compounds

A new series of 2-phenyl-3-(6-aryl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-3-yl)-4H-4-chromenone 1(a-j) has been synthesized by the reaction of 3(4-amino-5-sulfanyl-4H-1,2,4-triazol-3-yl)-2-phenyl-4H-4-chromenone with a variety of phenacyl bromides in ethanol under reflux. The compound with the 4-bromophenyl (1g) greatest anti A. niger action, while compound (1a) had the least. Except for 1a and 1i, these compounds also shown efficacy against Candida albicans. While others showed moderate to good action, the compound containing the 4-methoxyphenyl (1c) good activity against C. albicans.