CHARACTERISTICS OF THE LEVEL OF SPONTANEOUS ACTIVATION OF BLOOD BASOPHILS TO TOOTHPASTES IN CHILDREN WITH ALLERGIC DISEASES

test of spontaneous activation of basophils, toothpastes, allergy Annotation: Many literature data show that plaque is one of the most important etiological and etiological links in the development of caries and inflammatory periodontal disease, and that effective oral hygiene is the main method of removing plaque.It has been established that the most important and effective way to control plaque is to perform oral hygiene at least 1-2 times a day at home.Traditionally, experts recommend using toothbrushes and toothpaste for this.Toothpaste is a complex system, the formation of which includes abrasives, humectants, binders, foaming agents, surfactant components, perfume fillers, and pharmaceutical additives.Toothpaste is designed for specific user groups, taking into account age and the state of oral organs and tissues.The effectiveness of toothpaste has been proven by recent studies [1-7].But today when choosing toothpaste, somatic diseases in children are not taken into account.Up to 30% of the population in highly developed countries suffers from allergic diseases.Prevalence of atopic (IgE antibody-mediated) diseases: the incidence of atopic dermatitis in the population is 10-15%, allergic rhinitis - 23-28%, bronchial asthma - 5.4%.In 40-60% of patients, complex allergic damage to the skin, respiratory tract, and gastrointestinal tract is detected [8].The increase in the incidence of allergic diseases indicates that environmental factors have an impact on the manifestation of genetic predisposition.Functional gene polymorphisms may determine differences in vulnerability to environmental factors, highlighting the complexity of gene-environment interactions.This area is not yet well understood.Currently, CAST tests are used to diagnose allergies.This method has 100% specificity, which greatly complements the measurement of IgE antibodies. The use of CAST tests avoids the use of life-threatening induced tests and does not pose any risk to the patient [9-11]. The CAST test has been found to be applicable to the diagnosis of drug allergies to antibiotics, painkillers, anesthetics, muscle relaxants, etc., as well as allergies to insect bites (bees, wasps, cockroaches, fleas), inhalation allergens, and food additives (preservatives, coloring agents).Specialized allergens (latex, chloramine, formaldehyde, etc.).