COMPREHENSIVE REVIEW ON FORMULATION AND MANUFACTURING TECHNIQUES OF BILAYER TABLETS

Bilayer tablets are an inventive and adaptable drug delivery device because they have two layers, each with a unique drug release profile. This review summarises the development, manufacturing processes, formulation strategies, and pharmaceutical uses of bilayer tablets. Carefully choosing formulation ingredients is essential to the effectiveness of these tablets, taking into account medication compatibility as well as the effects of formulation variables on stability and bioavailability. A range of manufacturing approaches are examined, emphasising their scalability and appropriateness for certain medication classes. These techniques include direct compression, compression coating, and stacking. The reliability of bilayer tablets is mostly dependent on quality control, which emphasises friability, disintegration, and dissolving testing. Bilayer tablets have been used pharmaceutically to treat problems of the central nervous system, the heart, and the gastrointestinal tract, proving their effectiveness in treating complicated medical illnesses. Novel approaches to medication delivery have been made possible by recent developments in bilayer tablet technology, including the incorporation of developing materials and applications of nanotechnology. Exciting future potential include personalised medical techniques and the use of 3D printing technology for customised bilayer tablets. To sum up, this extensive analysis offers a complete grasp of bilayer tablets and offers insightful information about their production, composition, and range of medical uses. By combining cutting-edge technologies, bilayer tablets are positioned as a flexible and promising drug delivery method that will promote improvements in patient-specific therapies and enhance treatment results.