Novel Therapeutic Approach for Evaluation on Traumatic Brain Injury

Traumatic brain injury (TBI) can manifest in a variety of ways, from slight changes in consciousness to a fully unconscious, lifeless state and even death. Diffuse type damage and edema involve the entire brain in the most severe kind of traumatic brain injury. Depending on how severe the injury is, there are many different treatment options available, ranging from drastic surgery like bilateral decompressivecraniectomy to daily cognitive therapy sessions. There are established guidelines for the best treatment of traumatic brain injury (TBI), but they must be used situation-specifically and should not be applied blindly. Also some of the treatment can cause side effect so more of the new strategies are required which may include therapeutic targets. Therapeutic targets are biological molecules, biological pathways, or physiological responses linked to specific disease processes that can be positively or negatively altered by therapy to alter the disease's course. In this overview, Nrf2, IL-1, Glutamate, Mitogen-activated protein kinase, C-C chemokine receptor 5 are briefly reviewed. Making change in these therapeutic targets can help in treatingTBI