GLUCOCORTICOIDS INDUCED OSTEOPOROSIS: A MEDICINE INDUCED DISEASE

Diseases such as cancer, inflammation, respiratory, and autoimmune diseases are treated or managed using glucocorticoids (GCs), but this GC therapy has a significant side effect, which is the induction of osteoporosis, also termed glucocorticoids-induced osteoporosis (GIOP). The GIOP leads to an increase in bone absorption through decreasing the level of osteoblasts (bone-forming cells) and increasing the level of osteoclasts (bone-deleting cells), which leads to suppression of bone formation.