A Comparative Study of Anthelmintic Activity of Hydroalcoholic Extract & Petroleum Ether Extract of Pumpkin Seeds

Helminthiasis remains a significant public health concern, particularly in tropical and subtropical regions, prompting a continuous search for effective and safer anthelmintic agents.1 In recent years, natural plant- based remedies have garnered attention as potential alternatives to synthetic drugs. This review focuses on the comparative study of the anthelmintic activity of hydroalcoholic extract and petroleum ether extract (0il phase) of pumpkin seeds (Cucurbita spp.) using earthworms. Commonly Pheretima posthuma —as in vitro models due to their physiological resemblance to parasitic helminths.2 The study consolidates findings on extract preparation methods, tested concentrations, observed paralysis and death times, and comparative effectiveness with standard anthelmintic drugs like albendazole. Results from multiple studies indicate that pumpkin seed extract exhibit promising anthelmintic properties, often attributed to the presence of phytoconstituents such as tannins, alkaloids, flavanoids & saponins. This study highlight the comparative study of hydroalcoholic extract & petroleum ether extract of pumpkin seeds & advocates for further pharmacological & clinical validation to establish their efficacy & safety profiles for use in both human & veterinary medicine.