Transferosomes, Revolutionizing NSAIDS Delivery For Improved Therapeutic Efficacy: A Systematic Review Of Formulation Strategies And Evaluations

Non-steroidal anti-inflammatory medicines, or NSAIDs, are becoming becoming increasingly common due to their widespread acceptance as necessary medications for the efficient treatment of pain and inflammation. They possess antipyretic, analgesic, and anti-inflammatory characteristics. On the other hand, taking NSAIDs orally can result in a number of adverse effects in gastrointestinal tract, pulmonary, cardiovascular systems. As a result, transdermal NSAIDs application were suggested over the oral NSAID administration for the treatment of pain and inflammation. Medication applied directly to the skin is meant to have either systemic or local effects. Nanovesicles are extremely promising therapeutic agents for the treatment of cancer, inflammatory infections, and degenerative diseases. Phospholipid vesicles known as transfersomes are specifically employed as drug carriers for transdermal delivery, offering a novel therapeutic strategy. The present review article emphasis the composition, penetration mechanisms, production processes, and characterization techniques of transferosomes, as transdermal delivery system of drugs